Fisetin is a strong anti-oxidant that has also been proven to have potent senolytic effects. It has been shown to help remove senescent or damaged cells and to prevent the replication of damaged DNA. In doing so, it promotes human health and lifespan and has a role in aging and age-related diseases. Research has shown that Fisetin extends lifespan by reducing oxidative stress and increasing glutathione levels. It supports healthy aging and fights chronic disease.

Research has shown that fisetin reduces senescence markers. It has twice the senolytic potency as quercetin.

Fisetin, like other polyphenols such as Resveratrol, is a sirtuin-activating compound and has been shown in laboratory studies to extend the life of yeast, worms, flies, and mice.

Fisetin has shown anti-cancer activity in studies on cells and model animals conducted in laboratories, and it appears to block the PI3K/AKT/mTOR pathway, along with other mechanisms to induce apoptosis activation, and prevent apoptosis resistance.

Studies also have shown that Fisetin induces cardiac regeneration by activating genes involved in cell proliferation. It potentially protects from ischemic damage after a heart attack and may help prevent strokes.

Finally, Fisetin (like quercetin) seems to improve blood clotting time and thrombin time.