Full Health | Natural Vitamin B12 Drops 200 μg 50 ml

Full Health Natural Vitamin B12 Drops 200 μg – 50 ml

Dietary supplement with Vitamin B12 as drops, in the bioavailable form of methylcobalamin, with plant-derived glycerin as a natural solvent — alcohol-free, no sweeteners, no artificial colors or flavors.

Key Features

• Vitamin B12 in the bioavailable form of methylcobalamin
• 200 μg per drop — flexible dosing, easy to adjust to individual needs or split across the day for maximum absorption
• Practical, economical packaging: 1,100 drops per bottle
• Sublingual application for absorption also via the oral mucosa
• Alcohol-free, no sweeteners, no artificial colors or flavors, no allergens, no preservatives
• Suitable for vegans
• Tested for heavy metals in accordance with Commission Regulation (EC) No 2023/915

What is Vitamin B12?

Vitamin B12 is a water-soluble vitamin, with methylcobalamin being its bioactive form.

Benefits of Vitamin B12

Vitamin B12 contributes to normal energy-yielding metabolism (EFSA Journal reference: 2009;7(9):1223).*

At the mechanistic level, Vitamin B12 is essential for the conversion of methylmalonyl-CoA to succinyl-CoA, a metabolite that fuels mitochondrial metabolism and the Krebs cycle. In cases of deficiency, this pathway is disrupted (Takahashi-Iñiguez et al., 2012).**

Vitamin B12 contributes to the normal functioning of the nervous system (EFSA Journal reference: 2010;8(10):4114).*

Vitamin B12 plays a key role in the synthesis and maintenance of myelin, the protective sheath around nerves that enables rapid transmission of nerve signals. Deficiency has been associated with numbness, tingling, gait problems, and other neurological changes (Gao et al., 2018).**

Vitamin B12 contributes to normal homocysteine metabolism (EFSA Journal reference: 2010;8(10):4114).*

Methionine synthase uses Vitamin B12 to remethylate homocysteine to methionine. When B12 levels are low, this reaction slows and homocysteine levels rise (Hoffbrand & Jackson, 1993a; Sauer & Wilmanns, 1977).**

Vitamin B12 contributes to normal psychological function (EFSA Journal reference: 2010;8(10):4114).*

Adequate Vitamin B12 supports the availability of methionine/SAM for methylation reactions in the brain. Deficiency has been linked to mood, cognitive, and neuropsychiatric symptoms (Fernàndez-Roig et al., 2012; Smith et al., 2018).**

Vitamin B12 contributes to normal red blood cell formation (EFSA Journal reference: 2009;7(9):1223).*

Bone marrow erythroblasts divide rapidly and depend on normal DNA synthesis. Via the methionine synthase reaction, Vitamin B12 regenerates THF, which is essential for purine and thymidylate synthesis. When B12 is deficient, folate becomes "trapped" in an unusable form, impairing red blood cell maturation (Hoffbrand & Jackson, 1993b; Koury & Ponka, 2004). Deficiency can lead to megaloblastic anemia, causing fatigue, weakness, pallor, and breathlessness (Ankar & Kumar, 2026).**

Vitamin B12 contributes to the normal function of the immune system (EFSA Journal reference: 2009;7(9):1223).*

Immune cells are rapidly proliferating cells that depend on normal DNA synthesis and cell division. B12 deficiency may impair immune cell maturation and function.**

*Official health claims by EFSA.

**Information is based on published studies and articles in peer-reviewed scientific journals and does not constitute official health claims by EFSA. For more information, refer to the "Warnings – Labeling" and "Bibliography" sections.

Additional Information

Dietary Sources, Bioavailability & NRV

Vitamin B12 is found naturally only in animal-derived foods (fish, meat, poultry, eggs, dairy). Some plant foods are fortified with B12 (e.g., breakfast cereals, nutritional yeast). Bioavailability varies by food type — dairy provides approximately three times higher bioavailability than meat, fish, or poultry, while B12 from supplements is approximately 50% more bioavailable than from food. The recommended daily intake ranges from 2.4–2.8 μg for adults and 0.4–2.8 μg for infants, children, and adolescents depending on age. (Allen, 2010; Damayanti et al., 2018; Henjum et al., 2020; Vogiatzoglou et al., 2009; Watanabe et al., 2014)**

How is Vitamin B12 Absorbed?

From food, B12 is bound to proteins and must be released before absorption — a process beginning in the mouth and continuing in the stomach (via hydrochloric acid and protease), where it binds to haptocorrin. In the duodenum, digestive enzymes release B12 from haptocorrin; it then binds to intrinsic factor and is absorbed in the upper ileum via receptor-mediated endocytosis. (Dietary Reference Intakes, 1998)

From supplements, B12 is already in free form. A small amount can be absorbed passively via mucous membranes (including the mouth), and approximately 1–2% of an oral dose is absorbed passively along the GI tract. The intrinsic factor pathway can handle approximately 1–2 μg per meal, with a recovery time of 4–6 hours. (Allen, 2010; Smith et al., 2018)**

How Do We Know if We're Deficient?

B12 levels are measured in serum or plasma; values below 200–250 pg/mL are generally considered below normal. Methylmalonic acid (MMA) is a highly sensitive biomarker used to detect functional B12 deficiency. Always consult your doctor for assessment. (Allen et al., 2018; Langan & Goodbred, 2017)**

Groups at Risk of Deficiency

• Older adults (65+): Reduced intrinsic factor production and gastric acid secretion; increased risk of H. pylori infection impairing absorption. (Pfisterer et al., 2016; Wong, 2015)
• Individuals with GI disorders (e.g., celiac disease, Crohn's disease): May not absorb sufficient B12 from food. (Cavalcoli et al., 2017; Gomollón et al., 2017)
• Post-GI surgery: Procedures such as gastric bypass may result in partial or complete loss of intrinsic factor-secreting cells. (Pan et al., 2017; Ward et al., 2015)
• Vegans and vegetarians: Higher risk due to absence of animal-derived foods. (Pawlak et al., 2014; Piccoli et al., 2015)**

Upper Limits & Drug Interactions

Vitamin B12 has no established upper intake level in Europe and is considered safe even at high doses.

Certain medications may negatively affect B12 levels — including proton pump inhibitors (e.g., omeprazole, lansoprazole), H2 receptor antagonists (e.g., cimetidine, ranitidine), and metformin. Individuals taking these medications regularly should discuss their B12 status with their doctor. (Dietary Reference Intakes, 1998; Jung et al., 2015; Lam et al., 2013; Miller, 2018)**

Form, Packaging & Quality

Packaged in a 50 ml dark glass bottle (1,100 drops) with a black cap, rubber stopper, and glass pipette. Compliant with food contact material regulations: Regulation (EC) 1935/2004 and Regulation (EU) 10/2011.

Important: Free from artificial colors, flavors, preservatives, magnesium stearate, and controversial excipients. Tested for heavy metals, pathogens, sulfur dioxide, and sulfites. Free from gluten (including traces), shellfish, egg, tree nuts, soy, lactose, dairy, and sugar. Suitable for vegans.

Ingredients

Methylcobalamin, vegetable glycerin, purified water.

Free from: Artificial colors, flavors, preservatives, controversial excipients, and genetically modified ingredients.

Nutrition Table

*NRV = Nutrient Reference Value

Directions & Dosage

Take 1–2 drops daily, ideally directly under the tongue or as directed by a healthcare professional.

Warnings & Labeling

Do not exceed the recommended daily dose. Food supplements should not be used as a substitute for a balanced diet. This product is not intended for the prevention, treatment, or cure of human disease. Consult your doctor if you are pregnant, breastfeeding, on medication, or have health issues. Keep out of reach of children.

The information provided is based on published studies in peer-reviewed scientific journals and does not constitute official EFSA health claims. We encourage you to consult healthcare professionals (physician, pharmacist, dietitian-nutritionist) for the use of food supplements.

EOF Notification No.: 131964/06-11-2025. This product is not subject to a licensing procedure.

Bibliography

Allen, L. H. (2010). Bioavailability of Vitamin B12. International Journal for Vitamin and Nutrition Research, 80(45), 330–335.
Allen, L. H., et al. (2018). Biomarkers of Nutrition for Development (BOND): Vitamin B-12 Review. The Journal of Nutrition, 148, 1995S–2027S.
Ankar, A., & Kumar, A. (2026). Vitamin B12 Deficiency.
Cavalcoli, F., et al. (2017). World Journal of Gastroenterology, 23(4), 563.
Damayanti, D., et al. (2018). Nutrients, 10(6), 722.
Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. (1998). National Academies Press.
Dogan, K., et al. (2014). Medicine, 93(25), e169.
Fernàndez-Roig, S., et al. (2012). Nutrition & Metabolism, 9(1), 41.
Gao, J., et al. (2018). Neurotherapeutics, 15(1), 156–175.
Gomollón, F., et al. (2017). Nutrients, 9(3), 308.
Henjum, S., et al. (2020). European Journal of Clinical Nutrition, 74(5), 749–756.
Hoffbrand, A. V., & Jackson, B. F. A. (1993a). British Journal of Haematology, 83(4), 643–647.
Jung, S. B., et al. (2015). Internal Medicine Journal, 45(4), 409–416.
Koury, M. J., & Ponka, P. (2004). Annual Review of Nutrition, 24(1), 105–131.
Lam, J. R., et al. (2013). JAMA, 310(22), 2435.
Langan, R. C., & Goodbred, A. J. (2017). American Family Physician, 96(6), 384–389.
Miller, J. W. (2018). Advances in Nutrition, 9(4), 511S–518S.
Pan, Y., et al. (2017). Nutrients, 9(4), 382.
Pawlak, R., et al. (2014). European Journal of Clinical Nutrition, 68(5), 541–548.
Pfisterer, K. J., et al. (2016). Applied Physiology, Nutrition, and Metabolism, 41(2), 219–222.
Piccoli, G., et al. (2015). BJOG, 122(5), 623–633.
Sauer, H., & Wilmanns, W. (1977). British Journal of Haematology, 36(2), 189–198.
Smith, A. D., et al. (2018). Vitamin B12 (pp. 215–279).
Takahashi-Iñiguez, T., et al. (2012). Journal of Zhejiang University Science B, 13(6), 423–437.
Tamura, J., et al. (2001). Clinical and Experimental Immunology, 116(1), 28–32.
Vogiatzoglou, A., et al. (2009). The American Journal of Clinical Nutrition, 89(4), 1078–1087.
Ward, M. G., et al. (2015). Inflammatory Bowel Diseases, 21(12), 2839–2847.
Watanabe, F., et al. (2014). Nutrients, 6(5), 1861–1873.
Wong, C. (2015). Hong Kong Medical Journal.