D-Serine is an amino acid naturally found in the brain that activates a type of neurotransmitter receptor called NMDA (N-methyl-D-aspartate). NMDA receptors are involved in the formation of new synapses, which are critical for learning and memory. D-Serine is derived from glycine and acts as a neuromodulator — regulating the activity of neurons and improving the effects of other compounds that bind to NMDA receptors, including glutamate.
D-Serine is found naturally in foods such as soybeans, nuts (peanuts, almonds, walnuts), eggs, chickpeas, lentils, meat, and shellfish. The body can also produce it when dietary intake is insufficient.
Key Benefits
- Cognitive support: May help reduce symptoms of cognitive decline, including memory and thinking skills
- NMDA receptor activation: Supports healthy brain signalling and synaptic plasticity
- Neurological health: Studied for use in schizophrenia, Parkinson’s disease, depression, and insomnia
- Neuromodulation: Enhances the effects of glutamate and other NMDA-binding compounds
- Brain signalling: Sends chemical signals that may support various brain conditions
How Does D-Serine Work?
D-Serine is a co-agonist at NMDA receptors, meaning it improves the effects of other compounds that bind to the receptor, including glutamate and NMDA itself. D-Serine supplementation can reduce symptoms of cognitive decline and may help with diseases characterised by reduced NMDA signalling, such as schizophrenia and cocaine dependence. It sends chemical signals in the brain that might help with various neurological conditions including Parkinson’s disease, depression, and insomnia.
Quality & Purity
Lab-certified 99%+ pure powder. Natural product extracted from Oleaceae. EU-tested and verified through independent 3rd-party laboratory analysis.
📄 View Certificate of Analysis (COA)
Dosing & Storage
Recommended daily dose: 2g to 4g. Do not exceed.
Best taken as a powder mixed with water or juice. Temperature stable, but refrigeration is recommended when possible. For long-term storage, can be placed in the freezer.
A free measuring spoon is included. The spoon holds 0.5g of D-Serine and is dishwasher safe. Note: density may vary between products — the spoon may hold a different mass for other powders. For greater precision, a precision scale is available in our store.
Shelf life: 2 years. Store in a cool, dark place. Keep away from children.
These statements have not been evaluated by the FDA, EMA or MHRA. Supplements are food products, not medicines, and as such cannot be used to diagnose, treat, cure, or prevent any disease. Food supplements should not be used as a substitute for a varied diet.
Frequently Asked Questions
What is D-Serine?
D-Serine is an amino acid naturally found in the brain. It acts as a neuromodulator, meaning it helps regulate neuronal activity. D-Serine is involved in activating NMDA (N-methyl-D-aspartate) receptors, which play a critical role in learning, memory, and overall cognitive function.
What are the benefits of D-Serine?
D-Serine is studied for its potential benefits in supporting cognitive function and neurological health. Research suggests it may help with:
- Cognitive decline, including memory and thinking skills
- Schizophrenia, as it supports NMDA receptor function
- Depression and insomnia by influencing brain signalling
- Parkinson’s disease and other neurological disorders
D-Serine also helps regulate chemical signals in the brain, improving the effects of other compounds that bind to NMDA receptors, including glutamate.
What foods contain D-Serine?
D-Serine can be found in various foods, including:
- Soybeans
- Nuts such as peanuts, almonds, and walnuts
- Eggs
- Chickpeas and lentils
- Meat
- Shellfish
The body can also produce D-Serine when dietary intake is insufficient.
How should I take D-Serine?
D-Serine is best taken as a powder mixed with water or juice. It is temperature stable, but it is recommended to keep it refrigerated whenever possible. For long-term storage, it can be placed in the freezer.
How much D-Serine should I take?
The recommended daily dose of D-Serine is 2 to 4 grams. Do not exceed this dosage. Hansen Supplements provides a free measuring spoon with each product. The spoon holds 0.5 grams of D-Serine and is dishwasher safe. If greater precision is needed, we recommend using a precision scale, available for purchase in our store.
Is D-Serine safe for long-term use?
D-Serine is generally well-tolerated when taken within the recommended dosages. However, high doses may temporarily affect kidney function, so individuals with kidney issues should consult a healthcare provider before taking D-Serine supplements.
Can D-Serine be taken with other supplements or medications?
D-Serine interacts with NMDA receptors and may influence the effects of certain medications, particularly those that affect brain function, such as:
- Antipsychotic medications
- NMDA receptor antagonists
- Cognitive-enhancing compounds
Are there any contraindications for D-Serine use?
D-Serine should be used with caution if you have:
- Kidney disease
- A history of seizures
- Schizophrenia (only use under medical supervision)
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